Solanum glaucophyllum is a species of plant in the family Solanaceae. It is known as waxyleaf nightshade. It is native to Brazil, Bolivia, Argentina, Paraguay and Uruguay.

It is usually classified under the section Cyphomandropsis, within the subgenus Bassovia.

It is a rhizomatous plant with a simple stem and shortly branched, growing to tall or more. The leaves are simple, ovate, lanceolate, greenish-gray, and the plant produces long, bluish purple flowers. The fruit is a globose berry 1–2 cm in diameter, blue-black, and contains several seeds. The plant propagates vegetatively by gemmiferous roots of high regeneration capacity in water-saturated soils like edges of lakes.

It is poisonous to ruminants. It is one of the few plants that creates vitamin D.