Odontophrynus is a genus of frogs in the family Odontophrynidae. They are found in southern and eastern South America. They are sometimes known as the escuerzos.

Species: The genus contains the following species:

• Odontophrynus alipioi (Carvalho, 1946)
• Odontophrynus americanus (Duméril and Bibron, 1841)
• Odontophrynus carvalhoi Savage and Cei, 1965
• Odontophrynus cordobae Martino and Sinsch, 2002
• Odontophrynus cultripes Reinhardt and Lütken, 1862
• Odontophrynus juquinha Rocha, Sena, Pezzuti, Leite, Svartman, Rosset, Baldo, and Garcia, 2017
• Odontophrynus lavillai Cei, 1985
• Odontophrynus maisuma Rosset, 2008
• Odontophrynus monachus Caramaschi and Napoli, 2012
• Odontophrynus occidentalis (Berg, 1896)
• Odontophrynus reigi Rosset, Fadel, Guimarães, Carvalho, Ceron, Pedrozo, Serejo, Souza, Baldo, and Mângia, 2021