Iphiclus sedecimmaculatus is a Neotropical species of pleasing fungus beetle (family Erotylidae) described by Jean Buquet in 1840. It is characterized by sixteen prominent spots. This species occurs in the eastern foothills of the Andes, from Panama through Colombia, Peru and Brazil, to the lowlands of Paraguay.

Two varieties have been named, Iphiclus sedecimmaculatus var. concentratus by Crotch in 1876, and I.s. var. discedens by Kuhnt in 1910. They are nowadays treated as subspecies.

This beetle feeds on polypores (shelf fungi) as larvae and adults, as is typical for Erotylidae. Within its (possibly paraphyletic) genus, I.sedecimmaculatus is placed in the nominate subgenus Iphiclus (Iphiclus), which is possibly more closely related to genus Erotylina than to other lineages traditionally placed in Iphiclus. But I.sedecimmaculatus, like most of its presumed closest relatives, has a brownish pronotum with black spots, rather than the all-black pronotum found in most Erotylina.